产品货号：
Z21709
中文名称：
NOTCH2抗体
英文名称：
Anti-NOTCH2 Antibody
产品规格：
200μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NOTCH2 Antibody |
| 指标别名 | AGS2;hN2;Notch 2;Notch homolog 2 (Drosophila);NOTCH2 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,IHC,WB |
| 基因名称 | NOTCH2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acid residues 2390-2415 of human Notch 2 (the total protein is 2471 aa).?A residue of cysteine was added to the amino terminal end to facilitate coupling. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.1% (w/v) Sodium Azide |
| 纯化方式 | This antiserum is directed against human NOTCH 2.The peptide sequence shows 100% alignment with human,dog and chimpanzee sequence.Only one (1) amino acid difference is found in mouse and this change is non-conservative.Based on the sequence we expect this antibody to react as well with rat and mouse NOTCH 2.?No specific information is available for other reactivities. |
| 浓度 | 75mg/mL by Refractometry |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Anti Notch 2 Antibody recognizes Notch 2 that is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active,ligand-accessible form.Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC).Following ligand binding,it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.Notch functions as a receptor for membrane-bound ligands Jagged1,Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.Affects the implementation of differentiation,proliferation and apoptotic programs. |
| Uniprot ID | Q04721 |
| 推荐稀释比 | ELISA:1:30,000 - 1:90,000 IHC:1:200～1:800 WB:1:400 - 1:2,000 |
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